Dialogue
Blood clots is because of blood solidification and you can unusual viscosity due to obstacles impacting their fluidity; so it contributes to the synthesis of thrombocytes and you may activation off bloodstream coagulation grounds (8–10). Thus, fixing blood viscosity and you will improving blood coagulation setting spiders keeps a keen essential part regarding protection and therapy of DVT.
Our very own studies showed that to possess 3 days and you may ten months after DVT acting, hemorheology and coagulation spiders had been a knowledgeable throughout the highest-amount folic acid and you will vitamin B12 class. Specific account enjoys suggested you to definitely Hcy is actually good thrombus-developing representative, and higher Hcy you will create strong venous thrombosis (14–17). On the other hand, plasma D-dimer might have been proposed having a beneficial forewarning setting to possess blood clots and you may hypercoagulable condition (18,19). 10 weeks just after DVT modeling, i found that the levels out-of Hcy and you may D-dimer improved probably the most regarding the higher-serving class.
Using histopathologic examination, i found that ten months after DVT acting the high-dosage and you may lowest-dose communities shown high change in the alteration off down extremity deep venous thrombosis. Strong venous thrombosis off lower extremity with color Doppler ultrasound analysis has many gurus, such as easy operation, defense and you will high efficiency, discount, repeatability and you will lead observation, while the identification of relevant lesions and you will hemorrhaging possess to bloodstream ships (20). The abilities also showed that immediately after DVT modeling, new productive price out-of straight down extremity deep venous thrombosis treatment of high-dose class try one hundred%. The outcome away from colour Doppler ultrasound medical diagnosis regarding DVT corresponded to help you our very own findings into the histopathologic examination. That it verified brand new feasibility and energy conserving off color Doppler ultrasound prognosis for deep venous thrombosis of one’s all the way down extremity.
Within the sumin B12 provides obvious therapeutic consequences from inside the a bunny model off DVT which have hyperhomocysteinemia. The higher-amounts i attempted improved certain related periods, such as the degrees of Hcy and you may D-dimer, hemorheology, coagulation form, and you may vein pathology. Total, this research support the usage of higher doses out of folic acid and vitamin B12 to relieve DVT.
References
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